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BRCA 1 & 2 Mutation Test for Breast/Ovarian Cancers

BRCA 1 & 2 Mutation Test for Breast/Ovarian Cancers
N 78900
BRCA 1 & 2 Mutation Test for Breast/Ovarian Cancers BRCA 1 & 2 Mutation Test for Breast/Ovarian Cancers

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You will provide

Blood or Saliva Sample

This test is for both

Male, Female

Test Preparation

No specific preparation needed 



Tests Included (2 tests)

  • BRCA2 Mutation Analysis (Sequencing)
  • BRCA1 Mutation Analysis (Sequencing)

What are BRCA mutations?

Things don’t usually go as scheduled inside your cells. Sometimes, cells develop too quickly or DNA becomes damaged. Certain proteins — referred to as tumor suppressor proteins — step in when these things manifest and tackle the problem by slowing cell development, mending damaged DNA, and even guiding some damaged cells to cease working altogether.

BRCA1 and BRCA2 are genes that code for tumor suppressor proteins. BRCA gene mutations might also make the body to build or fold these proteins inaccurately. This stops them from doing their duties.

Cancer can be triggered by cells that grow out of control or damaged DNA. The cancers most related with BRCA mutations are breast cancers and ovarian cancer.

BRCA mutations are rare, however they are inherited. The risk of having a BRCA mutation is connected to your family history.

You get two copies of each of your genes — one from each natural parent. If one of your parents carried a BRCA mutation, you have a 50 percent risk of having that mutation yourself.

If you have a family member with a recognized BRCA mutation or if you meet the screening recommendations, you can take a genetic test to examine for BRCA mutations. This test makes use of a small sample of blood or saliva and generally takes about one month to get results.

Cancer risk related with BRCA mutations

According to a research in JAMA, about 72 percent of women with a BRCA1 mutation and 69 percent of women with a BRCA2 mutation will obtain a breastcancers diagnosis at age 80 By comparison, about 12 percent of all women will increase breast cancer in their lifetimes.

This trend is true for ovarian cancer, too. The same research asserted that about 44 percent of women with a BRCA1 mutation and 17 percent of women with a BRCA2 mutation will get ovarian cancers diagnosis by age 80 this compares with 1.3 percent of all women who will develop ovariancancers in the period of their lifetimes.

BRCA mutations may possibly amplify the risk of other sorts of cancer. These consist of cancers of the fallopian tube, pancreas, and peritoneum and also skin cancers. Men with BRCA mutations also have a higher risk of breast, pancreas, and prostate cancer.

It’s essential to have in mind that having a BRCA mutation doesn’t imply that you’ll have cancers of any kind. While people with BRCA mutations do have a greater risk for these cancers, many people with BRCA mutations may not develop cancer at all.

Who should be tested?

To verify your risk factors for BRCA mutations, your doctor can use a screening tool to collect information about your personal and family history. You may be asked the following questions by your medical doctor:

Have you or a close relative done a breast cancer diagnosis before getting to age 50 or earlier than their menopause?

Have you or a close relative had cancer in the two breasts?

Have you or a close relative had breast and ovarian cancer?

Are you or a close relative a man had breast cancer?

Does any of your family have a known BRCA mutation?

What do I need to know if I test positive?

For individuals who get positive results from a genetic test for BRCA mutations, options encompass enhanced screening and risk-reducing procedures.

Enhanced screening generally implies commencing breast examinations and mammograms on time and having them more often. In addition to breast examinations, men with BRCA mutations may gain from routine screening for prostate cancer.

Some individual with BRCA mutations choose or go with risk-reducing procedures like surgeries to take out the fallopian tubes, ovaries, or breasts to considerably decrease the risk of developing cancer.

What should I do after the test?

It’s imperative to know and comprehend our risk for the BRCA gene mutation. If you have any of the risk factors mentioned earlier above, see your doctor about genetic testing and counseling. If you’ve been already diagnosed with ovarian cancer, you may desire to know if you have either of the two BRCA gene mutations.

If you get a positive test result, talk to your doctor about all of your preventive options.


Disclaimer: The information provided herein is for patient general knowledge only and should not be used during any medical emergency, for the diagnosis or treatment of any medical condition. Duplication for personal and commercial use must be authorized in writing by

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